This file is indexed.

/etc/boxshade/clust160.sim is in boxshade 3.3.1-8.

This file is owned by root:root, with mode 0o644.

The actual contents of the file can be viewed below.

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This file is a Amino-acid similarity file for use with BOX.
Is resembles the GCG  simplify.txt, but similarities contained
in this file are not automatically set-forming. This means:
The line 
I LVM     means that I is similar to L,V and M and also that
                     L,V,M are similar to I.
          It does not imply that L is similar to V or to M.
For achieving this, more lines (the next ones) are necessary.
Although is seems weird, this feature has been chosen DELIBERATELY
because I think it could be helpful in some cases.
Other format requirements are the same as for SIMPLIFY.TXT in the 
GCG-package.
..
F YW
Y WF
W YF
I LVM
L VMI
V MVI
R KH
K HR
H RK
G A
A GS
T S
S TA
D EN
E DQ
N QD
Q NE