/usr/share/perl5/Circos/Utils.pm is in circos 0.69.4+dfsg-1.
This file is owned by root:root, with mode 0o644.
The actual contents of the file can be viewed below.
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=pod
=head1 NAME
Circos::Utils - utility routines for Circos
=head1 SYNOPSIS
This module is not meant to be used directly.
=head1 DESCRIPTION
Circos is an application for the generation of publication-quality,
circularly composited renditions of genomic data and related
annotations.
Circos is particularly suited for visualizing alignments, conservation
and intra and inter-chromosomal relationships. However, Circos can be
used to plot any kind of 2D data in a circular layout - its use is not
limited to genomics. Circos' use of lines to relate position pairs
(ribbons add a thickness parameter to each end) is effective to
display relationships between objects or positions on one or more
scales.
All documentation is in the form of tutorials at L<http://www.circos.ca>.
=cut
# -------------------------------------------------------------------
use strict;
use warnings;
use base 'Exporter';
our @EXPORT = qw(
add_thousands_separator
compare_str
compare_strs
current_function
current_package
defined_and_zero
exists_parameter
extract_number
false_or_no
first_defined
get_file_annotation
get_hash_leaf
hide
is_blank
is_comment
is_hidden
is_in_list
is_integer
is_num_equal
is_num_notequal
is_number
list_has_defined
list_parameters
locate_file
log10
log2
make_list
make_set
match_string
not_defined_or_one
pairwise_and
pairwise_or
parse_as_rx
parse_csv
parse_options
put_between
remap
remap_int
remap_round
remap_to_list
remove_undef_keys
replace
round_custom
round_up
sample_list
seek_parameter
seek_parameter_glob
show
span_distance
str_to_list
strip_quotes
to_number
track_r0
track_r1
true_or_yes
use_set
);
use Carp qw( carp confess croak );
use Cwd;
use FindBin;
use File::Spec::Functions;
use Math::Round;
#use Memoize;
use List::MoreUtils qw(uniq);
use Params::Validate qw(:all);
use Regexp::Common qw(number);
use POSIX qw(floor ceil);
use lib "$FindBin::RealBin";
use lib "$FindBin::RealBin/../lib";
use lib "$FindBin::RealBin/lib";
use Circos::Constants;
use Circos::Debug;
use Circos::Error;
# -------------------------------------------------------------------
sub strip_quotes {
my $str = shift;
$str =~ s/^['"]//;
$str =~ s/['"]$//;
return $str;
}
# -------------------------------------------------------------------
sub make_list {
#
# if passed an array ref, dereferences it and returns a list
# if passed a list, returns the list
# if passed undef/false returns an empty list
#
my $obj = shift or return ();
if ( ref $obj eq 'ARRAY' ) {
return @$obj;
} else {
return ( $obj );
}
}
sub round_custom {
my ($x,$round_type) = @_;
if (! defined $round_type) {
return int $x;
} elsif ($round_type eq "round") {
return round $x;
} elsif ($round_type eq "floor") {
return floor $x;
} elsif ($round_type eq "ceil") {
return ceil $x;
}
}
sub to_number {
my $x = shift;
if($x =~ /($RE{num}{real})/) {
$x = $1;
}
return $x;
}
#################################################################
#
# 0 1 2 3 ... k k+1=list_max_idx
#
# 0 if value < min
# 1..k if min <= value <= max
# k if max < value
#
sub remap_to_list {
my ($value,$min,$max,$base,$list) = @_;
return undef if ref($list) ne "ARRAY";
my $list_max_idx = @$list-1;
my $idx;
if($list_max_idx == 0) {
$idx = 0;
} elsif ($value < $min) {
$idx = 0;
} elsif ($value >= $max) {
$idx = $list_max_idx;
} elsif ($list_max_idx == 1) {
# if we have only two elements, any value <= max is the first color
$idx = 0;
} elsif ($list_max_idx == 2) {
# if we have three elements, any min <= value <= max is the middle element
$idx = 1;
} else {
my $value_remap = remap($value,$min,$max,1,$list_max_idx);
$value_remap = $value_remap ** (1/$base) if defined $base;
$idx = int $value_remap;
}
return $list->[$idx];
}
sub remap {
my ($value,$min,$max,$remap_min,$remap_max) = @_;
if (! defined $value ||
! defined $min ||
! defined $max ||
! defined $remap_min ||
! defined $remap_max) {
fatal_error("function","remap_wrong_num_args");
}
return $remap_min if $value <= $min;
return $remap_max if $value >= $max;
if ($min == $max) {
if ($remap_min == $remap_max) {
return $remap_min;
} else {
fatal_error("function","remap_min_max",$min,$max,$remap_min,$remap_max);
}
}
my $f = ( $value - $min ) / ( $max - $min );
my $value_remap = $remap_min + $f * ($remap_max - $remap_min);
#printinfo($value,$min,$max,$remap_min,$remap_max,$value_remap);
return $value_remap;
}
sub pairwise_or {
my ($a,$b,$x,$y) = @_;
if (! defined $a || ! defined $b || ! defined $x || ! defined $y) {
fatal_error("function","pairwise","pairwise_or",$a,$b,$x,$y);
} else {
return ($a eq $x && $b eq $y) || ($a eq $y && $b eq $x)
}
}
sub pairwise_and {
my ($a,$b,$x,$y) = @_;
if (! defined $a || ! defined $b || ! defined $x || ! defined $y) {
fatal_error("function","pairwise","pairwise_and",$a,$b,$x,$y);
} else {
return $a eq $x && $b eq $y;
}
}
sub remap_int {
return int remap(@_);
}
sub remap_round {
return round remap(@_);
}
sub track_r1 {
my ($counter,$t0,$tw,$tp) = @_;
my $r1 = sprintf("%fr",$t0+$counter*($tw+$tp)+$tw);
#printinfo("r1",$r1);
return $r1;
}
sub track_r0 {
my ($counter,$t0,$tw,$tp) = @_;
my $r0 = sprintf("%fr",$t0+$counter*($tw+$tp));
#printinfo("r0",$r0);
return $r0;
}
sub replace {
my ($x,$from,$to) = @_;
$x =~ s/$from/$to/ig;
return $x;
}
sub str_to_list {
my $str = shift;
return split(/\s*,\s*/, $str);
}
# -------------------------------------------------------------------
sub sample_list {
# Given a list and regular expression, return the elements in the
# list that match the regular expression.
#
# The results are sorted based on capture buffers from the regular expression.
my ($rx,$list) = @_;
my $rev = 0;
if ($rx =~ /rev\((.+)\)/) {
$rx = $1;
$rev = 1;
}
fatal_error("function","sample_list_bad_arg",$list,ref $list) unless ref($list) eq "ARRAY";
return undef if ! $list;
my @matches;
for my $item (@$list) {
if ($item =~ /^$rx$/) {
# pull out captured strings
my @captures = ();
for my $i (1..@+ - 1) {
my $str = substr($item,$-[$i],$+[$i]-$-[$i]);
push @captures, $str;
}
push @matches, {item=>$item,captures=>\@captures};
}
}
my @result = map { $_->{item} } sort { compare_strs($a->{captures},$b->{captures}) } @matches;
if ($rev) {
return reverse @result;
} else {
return @result;
}
}
sub parse_as_rx {
my $rx = shift;
return if ! defined $rx;
if ($rx =~ /^\s*-?\/(.+)\/\s*$/) {
return qr/$1/;
} else {
return;
}
}
sub is_num_equal {
my ($x,$y) = @_;
return unless defined $x && defined $y;
return $x == $y;
}
sub is_num_notequal {
my ($x,$y) = @_;
# return undef of neither inputs are defined
return if ! defined $x && ! defined $y;
# return true if only one input is undefined
return 1 if ! defined $x or ! defined $y;
# if both are defined, check if they match
return $x != $y;
}
sub match_string {
my ($str,$rx) = @_;
return unless defined $str;
return unless defined $rx;
if (ref($rx)) {
return $str =~ /$rx/;
} else {
return $str eq $rx;
}
}
# -------------------------------------------------------------------
sub compare_strs {
my ($list1,$list2) = @_;
my $result = 0;
for my $i (0..@$list1-1) {
return $result if ! defined $list1->[$i] || ! defined $list2->[$i];
$result ||= compare_str($list1->[$i],$list2->[$i]);
}
return $result;
}
# -------------------------------------------------------------------
sub extract_number {
my $str = shift;
if ($str =~ /0*(\d+)/) {
return $1;
} else {
return "";
}
}
# -------------------------------------------------------------------
sub compare_str {
my ($x,$y) = @_;
if ( $x =~ /$RE{num}{real}/ && $y =~ /$RE{num}{real}/ ) {
$x =~ s/^0*//;
$y =~ s/^0*//;
$x ||= 0;
$y ||= 0;
return $x <=> $y;
} else {
return $x cmp $y;
}
}
# -------------------------------------------------------------------
sub round_up {
my $value = shift;
if ($value > int($value)) {
return 1 + int($value);
} else {
return $value;
}
}
# -------------------------------------------------------------------
sub put_between {
my ($x,$min,$max) = @_;
return $min if $x < $min;
return $max if $x > $max;
return $x;
}
################################################################
#
sub is_number {
my ($x,$rxtype,$strict,$min,$max) = @_;
return if ! defined $x;
$strict = 1 if ! defined $strict;
my $pass = 1;
eval {
if ($x !~ /^$RE{num}{$rxtype}$/) {
$pass = 0;
fatal_error("parsedata","bad_number",$x,$rxtype) if $strict;
}
};
if ($@) {
fatal_error("parsedata","no_such_re",$x,$rxtype,$@);
}
return if ! $pass;
if ( (defined $min && $x < $min)
||
(defined $max && $x > $max)) {
my $min_text = defined $min ? $min : "(";
my $max_text = defined $max ? $max : ")";
$pass = 0;
fatal_error("parsedata","bad_number_range",$x,$rxtype,$min_text,$max_text) if $strict;
}
$pass ? return 1 : return;
}
sub is_integer {
return $_[0] == int( $_[0] );
}
sub is_blank {
my $string = shift;
return $string =~ /^\s*$/;
}
sub is_comment {
my $string = shift;
return $string =~ /^\s*\#/;
}
# -------------------------------------------------------------------
sub seek_parameter_glob {
my ( $param_name, $rewrite_rx, @data_structs ) = @_;
my @target_string = split( /\|/, $param_name );
my @param_rx = list_parameters(@data_structs);
my $params = {};
for my $param (@param_rx) {
if(grep($param =~ /$_/, @target_string)) {
my $value = seek_parameter($param,@data_structs);
if(defined $value) {
my $param_name = $param;
if($rewrite_rx) {
$param_name =~ s/$rewrite_rx//;
}
$params->{$param_name} = $value;
}
}
}
return $params;
}
# -------------------------------------------------------------------
sub seek_parameter {
# Given a parameter name and a list of hash references (or list
# references to hashes), looks for the parameter and returns the
# associated value. The parameter will also be extracted from any
# hash pointed to by the "param" key in the data structure.
#
# If the parameter name contains "|" then this is used as a
# delimiter to define synonyms of the parameter. This is helpful
# when parameters have changed names but you wish to maintain
# backward compatibility.
#
# value of x returned from $hash
# seek_parameter("x",$hash);
# value of x returned from $hash, and if not found, $anotherhash is tried
# seek_parameter("x",$hash,$anotherhash);
# value of x or y, whichever is seen first is returned
# seek_parameter("x|y",$hash,$anotherhash);
my ( $param_name, @data_structs ) = @_;
return seek_parameter_glob($param_name, @data_structs) if $param_name =~ /[*]/;
my @target_string = split( /\|/, $param_name );
my $not_def_ok = 1;
start_timer("parameter_seek");
for my $str (@target_string) {
for my $struct (@data_structs) {
if ( ref($struct) eq "ARRAY" ) {
for my $substruct (@$struct) {
if (exists $substruct->{param} &&
exists $substruct->{param}{$str} && ($not_def_ok || defined $substruct->{param}{$str})) {
stop_timer("parameter_seek");
return $substruct->{param}{$str};
}
if (exists $substruct->{$str} && ($not_def_ok || defined $substruct->{$str})) {
stop_timer("parameter_seek");
return $substruct->{$str};
}
}
} elsif ( ref($struct) eq "HASH" ) {
if (exists $struct->{param} &&
exists $struct->{param}{$str} &&
($not_def_ok || defined $struct->{param}{$str})) {
stop_timer("parameter_seek");
return $struct->{param}{$str};
}
if (exists $struct->{$str} && ($not_def_ok || defined $struct->{$str})) {
stop_timer("parameter_seek");
return $struct->{$str};
}
} else {
printdumper(\@data_structs);
confess "cannot extract parameter from this data structure (shown above - report this please)";
}
}
}
stop_timer("parameter_seek");
return undef;
}
# -------------------------------------------------------------------
sub exists_parameter {
# Like seek_parameter, but checks whether a parameter exists.
my ( $param_name, @data_structs ) = @_;
my @target_string = split( /\|/, $param_name );
start_timer("parameter_seek");
for my $str (@target_string) {
for my $struct (@data_structs) {
if ( ref($struct) eq "ARRAY" ) {
for my $substruct (@$struct) {
if (exists $substruct->{param} && exists $substruct->{param}{$str}) {
stop_timer("parameter_seek");
return 1;
}
if (exists $substruct->{$str}) {
stop_timer("parameter_seek");
return 1;
}
}
} elsif ( ref($struct) eq "HASH" ) {
if (exists $struct->{param} && exists $struct->{param}{$str}) {
stop_timer("parameter_seek");
return 1;
}
if (exists $struct->{$str}) {
stop_timer("parameter_seek");
return 1;
}
} else {
printdumper(\@data_structs);
confess "cannot extract parameter from this data structure (shown above - report this please)";
}
}
}
stop_timer("parameter_seek");
return 0;
}
# -------------------------------------------------------------------
sub list_parameters {
# List all populated parameters.
#
# list_parameters($hash);
# list_parameters($hash,$anotherhash);
my ( @data_structs ) = @_;
my @params = ();
start_timer("parameter_seek");
for my $struct (@data_structs) {
if ( ref($struct) eq "ARRAY" ) {
for my $substruct (@$struct) {
if (ref $substruct->{param} eq "HASH") {
push @params, grep(defined $substruct->{param}{$_}, keys %{$substruct->{param}});
}
if (ref $substruct eq "HASH") {
push @params, grep(defined $substruct->{$_}, keys %$substruct);
}
}
} elsif ( ref($struct) eq "HASH" ) {
if (ref $struct->{param} eq "HASH") {
push @params, grep(defined $struct->{param}{$_}, keys %{$struct->{param}});
}
if (ref $struct eq "HASH") {
push @params, grep(defined $struct->{$_}, keys %$struct);
}
}
}
stop_timer("parameter_seek");
return uniq @params;
}
sub is_hidden {
my @datapath = @_;
my $show_state = seek_parameter("show", @datapath);
return defined_and_zero($show_state);
}
sub get_file_annotation {
my %params = @_;
my $file = $params{file};
my ($filename,@annot) = split(",",$file);
return join(",",@annot);
}
# -------------------------------------------------------------------
sub locate_file {
my %params;
if ($Circos::Configuration::CONF{debug_validate}) {
%params = validate(@_,{
file => 1,
name => 0,
path => { type => ARRAYREF | UNDEF, optional => 1 },
return_undef => 0
});
} else {
%params = @_;
}
# v0.63 added configuration directory to dir_1
my @dir_1 = grep($_,getcwd,Circos::Configuration::fetch_conf("configdir"),$FindBin::RealBin,"/usr/share/circos");
my @dir_2 = qw(. .. ../.. ../../..);
my @dir_3 = qw(. etc data);
my $file = $params{file};
# remove any comma-delimited elements from the file
$file =~ s/,.*//;
# remove any trailing rx brackets from file
$file =~ s/\(.+?\)$//;
printdebug_group("io","locating file",$file,"role",$params{name});
if (! defined $file) {
confess "Attempted to locate an undefined file name for [$params{name}]";
}
my @path;
if (file_name_is_absolute($file)) {
@path = ($EMPTY_STR);
} else {
# first add any custom path directories
push @path, @{$params{path}} if defined $params{path};
if ( my $path_list = Circos::Configuration::fetch_conf("data_path") ) {
push @path, split($COMMA,$path_list);
}
# now the default locations
for my $d1 (@dir_1) {
for my $d2 (@dir_2) {
for my $d3 (@dir_3) {
push @path, catfile($d1,$d2,$d3);
}
}
}
}
printdebug_group("io","trying path",@path);
for my $path (@path) {
my $file_path = $path ? catfile($path,$file) : $file;
printdebug_group("io","trying $file_path");
if ( -e $file_path) {
if (! -r $file_path) {
fatal_error("io","cannot_read",$file,"with locate_file",$!);
} else {
printdebug_group("io","$file found in $file_path");
return $file_path;
}
}
}
if ( $params{return_undef} ) {
return undef;
} else {
fatal_error("io","cannot_find",$file,join("\n",map { " $_" } @path));
}
}
# -------------------------------------------------------------------
sub add_thousands_separator {
my $str = shift;
my $sep = shift || $COMMA;
if ( $str =~ /\./ ) {
$str =~ s/(?<=\d)(?=(\d{3})+\.)/,/g;
} else {
$str =~ s/(?<=\d)(?=(\d{3})+$)/,/g;
}
return $str;
}
# -------------------------------------------------------------------
sub not_defined_or_one {
return !defined $_[0] || $_[0];
}
# -------------------------------------------------------------------
sub defined_and_zero {
return defined $_[0] && !$_[0];
}
sub first_defined {
for (@_) {
return $_ if defined $_;
}
return;
}
sub list_has_defined {
return grep(defined $_, @_);
}
sub is_in_list {
my ($item,@list) = @_;
return scalar grep($item eq $_, @list);
}
# -------------------------------------------------------------------
sub current_function {
my ($package,$filename,$line,$function) = caller(1);
$function =~ s/.*:://g;
return $function;
}
sub current_package {
my ($package,$filename,$line,$function) = caller(1);
return $package;
}
# -------------------------------------------------------------------
# Parse a CSV list, respecting brackets and ,'s in values
#
# var1=a,var2=rgb(a,b,c),var3=a,b,var4=c
sub parse_csv {
my $str = shift;
my $delim = Circos::Configuration::fetch_conf("options_record_delim") || $COMMA;
my $assign = Circos::Configuration::fetch_conf("options_field_delim") || $EQUAL_SIGN;
my @elems = split("",$str);
my @params;
my $buffer = $EMPTY_STR;
my $paren_level;
while (scalar @elems) {
my $elem = shift @elems;
if ($elem eq "(") {
$paren_level++;
} elsif ($elem eq ")") {
$paren_level--;
} elsif ($elem !~ /$delim/i) {
$buffer .= $elem;
} elsif ($elem =~ /$delim/i) {
if (! $paren_level && $buffer =~ /$assign/i) {
$buffer =~ s/^$delim//g;
push @params, $buffer;
$buffer = $elem;
} elsif ($buffer !~ /$assign/i) {
$params[-1] .= $buffer;
$buffer = $elem;
} else {
$buffer .= $elem;
}
}
}
if($buffer ne $EMPTY_STR) {
if($buffer =~ /$assign/i) {
$buffer =~ s/^$delim//g;
push @params, $buffer if $buffer ne $EMPTY_STR;
} else {
$params[-1] .= $buffer;
}
}
if ($paren_level) {
fatal_error("parsedata","bad_csv",$str,$paren_level);
}
return @params;
}
sub remove_undef_keys {
my %x = @_;
return map { ($_,$x{$_}) } grep(defined $x{$_}, keys %x);
}
# return the distance between the span
# [x1,y1] and [x2,y2]
# if the spans overlap, the distance is negative
sub span_distance {
my ($x1,$y1,$x2,$y2) = @_;
# flip the coordinates if they are reversed
($x1,$y1) = ($y1,$x1) if $x1 > $y1;
($x2,$y2) = ($y2,$x2) if $x2 > $y2;
# flip intervals so that x1,y1 is always to the left
($x1,$y1,$x2,$y2) = ($x2,$y2,$x1,$y1) if ($x1 > $x2);
my $d;
if ($x2 >= $y1) {
# x1 y1
# -----
# x2 y2
# ------
$d = $x2 - $y1;
} else {
if ($y2 >= $y1) {
# x1 y1
# ---------
# x2 y2
# --------
$d = -($y1 - $x2);
} else {
# x1 y1
# ---------
# x2 y2
# ------
$d = -($y2-$x2);
}
}
die "did not calculate distance between intervals [$x1,$y1] and [$x2,$y2] correctly." unless defined $d;
return $d;
# test
for my $i (0..100000) {
my @coords = map { sprintf("%.1f",100*rand()) } (0..3);
my $s1 = Set::IntSpan->new(sprintf("%d-%d",sort {$a <=> $b} ($coords[0]*1000,$coords[1]*1000)));
my $s2 = Set::IntSpan->new(sprintf("%d-%d",sort {$a <=> $b} ($coords[2]*1000,$coords[3]*1000)));
my $int = $s1->intersect($s2)->cardinality;
my $d = span_distance(@coords);
if ($int) {
$int = ($int-1)/1000 if $int;
if ($int && (-$d - $int) > 0.002) {
die();
}
} else {
$int = min ( abs($coords[0] - $coords[2]),
abs($coords[0] - $coords[3]),
abs($coords[1] - $coords[2]),
abs($coords[1] - $coords[3]) );
if ($d - $int > 0.002) {
die();
}
}
printinfo(@coords,$d,$int);
}
}
sub make_set {
my ($x,$y,%args) = @_;
if (! defined $x) {
return Set::IntSpan->new();
} elsif (! defined $y || $x == $y) {
return Set::IntSpan->new(round $x);
} elsif ($x > $y) {
if ($args{norev} || defined_and_zero($args{rev})) {
fatal_error("data","malformed_span",$x,$y);
}
return Set::IntSpan->new( (round $y) . "-" . (round $x) );
} else {
return Set::IntSpan->new( (round $x) . "-" . (round $y) );
}
}
sub hide {
my @path = @_;
return defined_and_zero(seek_parameter("show|use",@path)) || seek_parameter("hide",@path);
}
sub use_set {
my @path = @_;
return not_defined_or_one(seek_parameter("use",@path))
}
sub show {
my @path = @_;
return ! hide(@path);
}
sub true_or_yes {
my $x = shift;
return if $x eq 1 || $x =~ /^y(es)?$/i;
}
sub false_or_no {
my $x = shift;
return if $x eq 0 || $x =~ /^no?$/i;
}
sub get_hash_leaf {
my ($hash,@path) = @_;
return $hash if ! @path;
my $key = shift @path;
if(! exists $hash->{$key}) {
fatal_error("system","hash_leaf_undef",$key);
} else {
return get_hash_leaf($hash->{$key},@path);
}
}
# -------------------------------------------------------------------
# parse into a hash option string like
# var1=value1,var2=value2,...
sub parse_options {
my $string = shift || $EMPTY_STR;
my $options = {};
my @option_pairs;
if ($string =~ /,[^=]*,/ || $string =~ /[()]/) {
# use the slower parser only when we know the options field includes brackets
# color=(255,0,0),x=1 -> color=(255,0,0) x=1
# or adjacent commas
@option_pairs = parse_csv($string);
} else {
@option_pairs = split(",",$string);
}
my %params;
#printdumper(\@option_pairs);
for my $option_pair ( @option_pairs ) {
if ($option_pair =~ /^([^=]+)=(.+)$/) {
$options->{$1} = $2;
} else {
fatal_error("parsedata","bad_options",$option_pair);
}
}
return $options;
}
sub log10 {
my $x = shift;
return $x > 0 ? log($x)/log(10) : undef;
}
sub log2 {
my $x = shift;
return $x > 0 ? log($x)/log(2) : undef;
}
1;
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